A tale of two subunits: KLH 1 and KLH 2 in Immucothel

A tale of two subunits: KLH 1 and KLH 2 in Immucothel

Themes of earthly duality have been inspirations throughout history, for example, compelling Charles Dickens to write about two contrasting cities, Goethe’s character Faust to lament the two competing souls in his breast and Shakespeare’s Hamlet to confront the choice between life and death. The exploration of dichotomies by novelists and poets has produced great works of literature and expanded our insights into the human situation. The same holds true for researchers and science.

Present investigations into the Keyhole Limpet Hemocyanin (KLH) keep elucidating its immunostimulatory function in vitro and in vivo. In biosyn’s most recent own “literary” work, the biochemical, immunological and structural similarities and dissimilarities between KLH’s two distinctive protagonists is the subject of deep narrative analysis. Maybe not quite as starkly contrasted as mid 19th Century London and revolutionary Paris, the tale of KLH 1 and KLH 2 reveals their divergent expression behavior. Enigmatically, the two KLH functional subunit isoforms are virtually inseparable, only divisible by complex processes. In solution, these two characters reassociate with like subunits. Their monomeric molecular weights are the same: 400,000, as are their number of functional unit domains: 8. These eight functional domains differ among themselves and between the isoforms. While native oligomers of KLH 1 only form didecamers, native oligomers of KLH 2 form both didecamers and oligomers. In certain physiological settings, KLH 1 may even completely exit the hemolymph “stage”. KLH thus consists of a xenogenic cocktail with 16 immunologically different functional domains. Unlike the didecamers of KLH 1, those of KLH 2 tend to combine with additional decamers to form high molecular multidecamers of varying length. Joined, they modify stably to create the immunotherapeutic agent immunocyanin. Back in vitro, the two didecamer and multidecamer isoforms reunite into the potent drug IMMUCOTHEL. Like inspiring characters from literature, Megathura crenulata and the dichotomous KLH subunits have versatile personalities and twisting, turning fortunes. In terms of plot, medical researchers have been producing material that expands our understanding of future benefits. In biosyn’s newly updated IMMUCOTHEL folder, the continued quest to modulate patients’ immune systems and advance pharmaceutical research to help cure disease is not only written between the lines therein.

To read more about the ongoing story of biosyn’s complementary and proprietary hemocyanin subunit formulations, download the updated folder:

  1. immunotherapy
  2. literature
  3. cancer
  4. immunocompetence